Fidel Nicolás Lolo, Víctor Jiménez-Jiménez, Miguel Sánchez-Álvarez & Miguel Ángel del Pozo.

Abstract: Tumor stiffening is a hallmark of malignancy that actively drives tumor progression and aggressiveness. Recent research hasshed light onto several molecular underpinnings of this biomechanical process, which has a reciprocal crosstalk between tumorcells, stromal fibroblasts, and extracellular matrix remodeling at its core. This dynamic communication shapes the tumormicroenvironment; significantly determines disease features including therapeutic resistance, relapse, or metastasis; and poten-tially holds the key for novel antitumor strategies. Caveolae and their components emerge as integrators of different aspects ofcell function, mechanotransduction, and ECM–cell interaction. Here, we review our current knowledge on the several pivotalroles of the essential caveolar component caveolin-1 in this multidirectional biomechanical crosstalk and highlight standingquestions in the field.

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