Miguel Sánchez-Álvarez & Miguel A. del Pozo.

Programmed cell death-ligand 1 (PD-L1)–mediated T cell inhibition through PD-1 is a key checkpoint frequently exploited by tumors to evade immunity. In this issue, Wang et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202108083) reveal an unexpected role for PD-L1 in promoting tumor cell front–rear polarity and directionally persistent cell migration, independently of PD-1.

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