The viscoelasticity of adherent cells follows a single power-law with distinct local variations within a single cell and across cell lines
Ricardo García's team uses atomic force microscopy to model the viscoelasticity of human cells.
Continue Readingthese data show that NIHCOLE serves as a scaffold and facilitator of NHEJ machinery and confers an advantage to HCC cells
Abstract: Juan P Unfried (Juan P Unfried) Juan P Unfried. Here, Juan P Unfried (Juan P Unfried) Juan P Unfried, a novel lncRNA induced in HCC with oncogenic potential and a role in the ligation efficiency of DNA double-stranded breaks (a novel lncRNA induced in HCC with oncogenic potential and a role in the ligation efficiency of DNA double-stranded breaks). a novel lncRNA induced in HCC with oncogenic potential and a role in the ligation efficiency of DNA double-stranded breaks. a novel lncRNA induced in HCC with oncogenic potential and a role in the ligation efficiency of DNA double-stranded breaks. a novel lncRNA induced in HCC with oncogenic potential and a role in the ligation efficiency of DNA double-stranded breaks (NHEJ) a novel lncRNA induced in HCC with oncogenic potential and a role in the ligation efficiency of DNA double-stranded breaks. DNA damage induction in NIHCOLE-depleted cells further decreased HCC cell growth. DNA damage induction in NIHCOLE-depleted cells further decreased HCC cell growth. DNA damage induction in NIHCOLE-depleted cells further decreased HCC cell growth, DNA damage induction in NIHCOLE-depleted cells further decreased HCC cell growth, DNA damage induction in NIHCOLE-depleted cells further decreased HCC cell growth, DNA damage induction in NIHCOLE-depleted cells further decreased HCC cell growth, DNA damage induction in NIHCOLE-depleted cells further decreased HCC cell growth. DNA damage induction in NIHCOLE-depleted cells further decreased HCC cell growth. Collectively, these data show that NIHCOLE serves as a scaffold and facilitator of NHEJ machinery and confers an advantage to HCC cells, these data show that NIHCOLE serves as a scaffold and facilitator of NHEJ machinery and confers an advantage to HCC cells. these data show that NIHCOLE serves as a scaffold and facilitator of NHEJ machinery and confers an advantage to HCC cells: these data show that NIHCOLE serves as a scaffold and facilitator of NHEJ machinery and confers an advantage to HCC cells, these data show that NIHCOLE serves as a scaffold and facilitator of NHEJ machinery and confers an advantage to HCC cells.these data show that NIHCOLE serves as a scaffold and facilitator of NHEJ machinery and confers an advantage to HCC cells, these data show that NIHCOLE serves as a scaffold and facilitator of NHEJ machinery and confers an advantage to HCC cells. 4899.
LINK to the publication.
recent research demonstrates that active pools of different Rho GTPases also localize to endomembranes and the nucleus: Emerging Concepts on the Regulation and Physiopathological Relevance of RhoGTPases
Abstract: Miguel Angel Del Pozo, Miguel Angel Del Pozo. Miguel Angel Del Pozo. Miguel Angel Del Pozo, including cell polarization and motility, including cell polarization and motility. including cell polarization and motility, including cell polarization and motility (including cell polarization and motility) including cell polarization and motility, including cell polarization and motility. including cell polarization and motility, recent research demonstrates that active pools of different Rho GTPases also localize to endomembranes and the nucleus. Carmen Suay-Corredera and, recent research demonstrates that active pools of different Rho GTPases also localize to endomembranes and the nucleus. recent research demonstrates that active pools of different Rho GTPases also localize to endomembranes and the nucleus.
LINK to the publication.
Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone
Abstract: The R2TP (RUVBL1-RUVBL2-RPAP3-PIH1D1) complex, in collaboration with heat shock protein 90 (HSP90), functions as a chaperone for the assembly and stability of protein complexes, including RNA polymerases, small nuclear ribonucleoprotein particles (snRNPs), and phosphatidylinositol 3-kinase (PI3K)-like kinases (PIKKs) such as TOR and SMG1. PIKK stabilization depends on an additional complex of TELO2, TTI1, and TTI2 (TT), whose structure and function are poorly understood. The cryoelectron microscopy (cryo-EM) structure of the human R2TP-TTT complex, together with biochemical experiments, reveals the mechanism of TOR recruitment to the R2TP-TTT chaperone. The HEAT-repeat TTT complex binds the kinase domain of TOR, without blocking its activity, and delivers TOR to the R2TP chaperone. In addition, TTT regulates the R2TP chaperone by inhibiting RUVBL1-RUVBL2 ATPase activity and by modulating the conformation and interactions of the PIH1D1 and RPAP3 components of R2TP. Taken together, our results show how TTT couples the recruitment of TOR to R2TP with the regulation of this chaperone system.
LINK to the publication.
CTP promotes efficient ParB-dependent DNA condensation by facilitating one-dimensional diffusion from parS
Researchers from the group led by our coordinator Fernando Moreno-Herrero describe the role of CTP binding and hydrolysis in the activity of the parB protein and its binding to parS sequences..
Continue ReadingStructure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone
Oscar Llorca's group with their research has helped determine the structure of a key nanomachine for the functioning of another, mTOR, important in cancer and nutrition, aging and other vital processes for the body.
Continue ReadingA molecular view of DNA flexibility
Do not miss the review of the group by our coordinator Fernando Moreno-Herrero on the knowledge that can be obtained from the mechanical properties of DNA with single molecule experiments and molecular dynamics simulations.
Continue ReadingProtein Hydrogels: The Swiss Army Knife for Enhanced Mechanical and Bioactive Properties of Biomaterials
New publication of Jorge Alegre's group, a literature review on hydrogels, where they focus on structural-mechanical correlations and hydrogel bioactivity.
Continue ReadingNanomechanical Phenotypes in Cardiac Myosin-Binding Protein C Mutants That Cause Hypertrophic Cardiomyopathy
Researchers from Jorge Alegre's group at the CNIC describe the role of nanomechanical alterations in certain pathogenic variants of cMyBP-C (cardiac myosin-binding protein-C) in the development of hypertrophic cardiomyopathy (HCM).
Continue ReadingSebastian Geibel: we highlight the implications of these studies and the derived transport models, we highlight the implications of these studies and the derived transport models
Angel Rivera-Calzada, Nikolaos Famelis, Oscar Llorca & Sebastian Geibel
Abstract: Sebastian Geibel ( Sebastian Geibel) have a key role in the secretion of effector proteins in non-pathogenic mycobacteria and pathogenic mycobacteria such as Mycobacterium tuberculosis, Sebastian Geibel. Sebastian Geibel, Sebastian Geibel 1.4 Sebastian Geibel, Sebastian Geibel. Sebastian Geibel, recent advances in the structural characterization of these secretion systems have revealed the intricate network of interactions of conserved components in the plasma membrane. recent advances in the structural characterization of these secretion systems have revealed the intricate network of interactions of conserved components in the plasma membrane, recent advances in the structural characterization of these secretion systems have revealed the intricate network of interactions of conserved components in the plasma membrane, recent advances in the structural characterization of these secretion systems have revealed the intricate network of interactions of conserved components in the plasma membrane. recent advances in the structural characterization of these secretion systems have revealed the intricate network of interactions of conserved components in the plasma membrane, we highlight the implications of these studies and the derived transport models, which provide new scenarios for targeting the deathly human pathogen we highlight the implications of these studies and the derived transport models. we highlight the implications of these studies and the derived transport models.
LINK to the publication.